| Customization: | Available |
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| Powder: | Yes |
| Customized: | Customized |
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Best Price Powder CAS 1270138-41-4 99% Nsi 189 Phosphate
| Product name | NSI-189 |
| CAS No. | 1270138-41-4 |
| Molecular Formula | C22H33N4O5P |
| Molecular Weight | 464.494981 |
| Purity | 99% |
NSI-189 is a nootropic and neurogenic research chemical derived from nicotinamide and pyrazine.IC50 value:Target: in vitro: NSI-189 has been shown to stimulate neurogenesis of human hippocampus-derived neural stem cells in vitro and in vivo. The hippocampus is responsible for the consolidation of information from short-term memory to long-term memory, along with spatial navigation [1] [2].in vivo: NSI-189 has been shown to increase the hippocampal volume of healthy adult mice by 20%
Tests have shown that NSI-189 significantly improved behavioral responses that are associated with depression . In humans it may counter hippocampal atrophy which is seen in disorders such as MDD, reversing their symptoms. A phase 1B randomized, double-blind, placebo-controlled, multiple-dose escalation study conducted over a 28 day period showed behavioral efficacy in 24 patients who were orally administered NSI-189 . The efficacy measurements showed a clinically meaningful reduction in cognitive and depressive symptoms across all measures, and appeared to persist over time during follow up for the efficacy assessments which included the Clinical Global Impression - Improvement (CGI-I), Montgomery-Aserb Depression Rating Scale (MADRS), Cognitive and Physical Functioning Questionnaire (CPFQ, and the Symptoms of Depression Questionnaire (SDQ) .
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Product name |
NSI-189 |
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| CAS No. |
1270138-40-3 |
Outer Packing | |
| Production date |
Dec. 15. 2016. |
Shelf life |
Dec. 14th. 2019 |
| Standard adopted |
in-house standard |
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| Items of analysis | Specification | Results | |
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Appearance |
Off-white powder |
Confrom |
|
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Identification |
IR and HPLC spectrum shall conform to the standard sample |
conform |
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Melting Point |
83ºC~86ºC |
84.3ºC~85.6ºC |
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Loss on Drying |
Less than 0.5% |
0.29% |
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|
Purity(On Dried Base,HPLC) |
NLT 99.5 % |
99.62% |
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Total Impurity |
Less than 0.5% |
0.33% |
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Residue On Ignition |
≤0.2% |
0.16% |
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Heavy metal |
≤20ppm |
conform |
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| Conclusion | Qualified | ||
Packaging Details:
25kgs packaging Fiber drum outside and plastic bag inside 1-25kgs packaging ;
aluminium bag outside and double plastic bag inside;
Delivery Detail:
Within 3 days when get the payment.
Shipping:
We have Professional shipping agent, based on customers ' demand for transport
By express :FEDEX,DHL,EMS ,UPS,TNT ect.
By SEA and By AIR.
Q1. What's the MOQ?
A: Usually 1 kg. It is based on the different product. Some are 1g and some are 1 ton. Please be free to consult our salesman.
Q2. What's the shipping time?
A: If in stock, we will ship it out immediately. By FeDex will be 3~5 days to you.
Q3. If I need less than the MOQ, is it possible?
A: Yes. Please be free to consult our salesman.
Q4. Can you supply the free sample?
A: Usually it is possible. It based on the different product. Please be free to consult our salesman.
Q5. How to store the product?
A: Store in cool and dry place. It must be in well closed containers.The shelf life will be 2 years.
Q6: What's your main payment method?
A: T/T, Western Union, Money Gram, Paypal.
Q7: Do you have COA, MSDS, CO, Health certificate, form 9 or other certificate?
A: Yes, we have. pls be free to contact us to get updated one.
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