| Type: | Powder |
|---|---|
| Function: | Powder |
| Main Ingredient: | Powder |
| Group: | All People |
| Certification: | GMP |
| Quality Guarantee Period: | Two Years |
| Samples: |
|---|
| Customization: |
|---|
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|
Product Name
|
Pharmaceutical Intermediate Semaglutide/Sermaglutide USP/EP/BP Semaglutide |
|
CAS NO
|
910463-68-2
|
|
Appearance
|
White Powder
|
|
Molecular Formula
|
C187H291N45O59
|
|
Storage
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Keep in a cool, dry, dark location
|
|
Shelf Life
|
24 months when properly stored
|
Sommarutide is a long-acting formulation based on the basic structure of Liraglutide, which is more effective in the treatment of type 2 diabetes. Sommarutide was prepared by solid-liquid synthesis method. Linear peptide Aib8, Arg34GLP-1(7-37) and aliphatic acylating agent were prepared by solid-phase synthesis. Under alkaline conditions, the synthetic aliphatic acylating agent was used to modify the linear peptide Lys26 to obtain sommaruteptide. The biological activity of the self-made samples was determined by time-resolved fluorescence resonance energy transfer immunoassay. |
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TEST ITEMS |
SPECIFICATION |
RESULTS |
|
Description |
White Crystalline Powder |
White Powder |
|
Identification |
Positive |
Positive |
|
Assay(by HPLC) |
98.0~102.0% |
98.64% |
|
Absorbance(E1cm) |
465~495 |
482.5 |
|
Melting Point |
191~195°C |
193.5~195.0°C |
|
Loss On Drying |
0.5%max |
0.19% |
|
Specific Rotation |
+288°~ +298° |
+290.2° |
|
Residue On Ignition |
0.1%max |
0.03% |
|
Related Substances |
Total:1.5%max |
<1.3% |
|
|
Single:0.5%max |
<0.4% |
|
Residue Solvents |
0.2%max |
0.10% |
|
Heavy Metals |
20PPm max |
<10PPm |
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|
|
|
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Conclusion |
The specification conform with enterprise standard. |
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