Pharmaceutical Raw Material API CAS 137862-53-4 Valsartan

• Powder: Yes
• Customized: Customized
• Certification: GMP, HSE, ISO 9001, USP, BP
• Suitable for: Elderly, Children, Adult
• State: Powder
• Purity: >99%
• Model NO.: HB-Valsartan
• Product Name: Valsartan
• CAS: 137862-53-4
• Assay: More Than 98%
• Grade: Medicine Grade
• Color: Fine White or off-White White Solid Powder
• Application: Pharmaceutical Grade and API
• Mf: C24h29n5o3
• MW: 435.519
• Test Method: HPLC
• MOQ: 1kg
• Sample: Available
• Stock: in Stock
• Certificate: Co, COA, MSDS
• Shipping Method: FedEx, DHL, TNT, EMS
• Transport Package: Foil Bag
• Specification: 99%
• Trademark: Herben
• Origin: China
• Production Capacity: 10000

Product Description

 

Product Description

 

Product Name: Valsartan
CAS No.: 137862-53-4
MF: C24H29N5O3
MW: 435.52
EINECS: 1592732-453-0
Mol File: 137862-53-4.mol
Melting Point: 116-117°C
Boiling Point: 684.9±65.0 °C(Predicted)
Density: 1.212±0.06 g/cm3(Predicted)

Valsartan (trade name Diovan) is an angiotensin II receptor antagonist (commonly called an ARB, or angiotensin receptor blocker), that is selective for the type I (AT1) angiotensin receptor. Valsartan is mainly used for treatment of high blood pressure, congestive heart failure, and to increase the chances of living longer after a heart attack.

Valsartan is used to treat high blood pressure, congestive heart failure, and to reduce death for people with left ventricular dysfunction after having had a heart attack. There is contradictory evidence with regard to treating people with heart failure with a combination of an angiotensin receptor blocker like valsartan and an angiotensin-converting enzyme inhibitor, with two major clinical trials (CHARM-additive and ValHeFt) showing a reduction in death, and two others (VALIANT and ONTARGET) showing no benefits, and more adverse effects including heart attacks. In people with type II diabetes and high blood pressure or albumin in the urine, valsartan is used to slow the worsening and the development end-stage renal disease.
 

Valsartan blocks the actions of angiotensin II, which include constricting blood vessels and activating aldosterone, to reduce blood pressure.The drug binds to angiotensin type I receptors (AT1), working as an antagonist. This mechanism of action is different than the ACE inhibitor drugs, which block the conversion of angiotensin I to angiotensin II. Since valsartan acts at the receptor, it can provide more complete angiotensin II antagonism since angiotensin II is generated by other enzymes as well as ACE. Also, valsartan does not affect the metabolism of bradykinin like ACE inhibitors do.
 

Specification

Test Items		Specifications		Results
Characters	Description	White or off-white powder. Odorless.		Conform
		*Slightly hygroscopy.		Conform
	*Solubility	Freely soluble in ethanol, practically insoluble in water		Conform
Identification		1) Infrared absorption spectrophotometry: corresponds to the reference standard.		Conform
		2) The retention time of the major peak in the chromatogram of the assay preparation corresponds to that of the standard preparation, as obtained in the Assay.		Conform
Water (KF)		≤2.0%		0.3%
Absorbance		≤0.02 (λ=420nm, C=0.05g/ml, L=1cm)		<0.01
Residue on ignition		≤0.1%		<0.1%
D-Valsartan (HPLC)		≤1.0%		0.22%
Related substances (HPLC)		Butyryl-Valsartan ≤0.2%		0.01%
		Benzyl-Valsartan ≤0.1%		<LOD(LOD:0.02%)
		Any other individual impurity≤0.10%		0.03%
		Total impurities excluding D-Valsartan≤0.3%		0.06%
Assay (HPLC)		98.0-102.0% (calculated on anhydrous,solvent-free basis)		99.7%
Conclusion		Complies with USP

 

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Packaging & Shipping

Packaging Details:
25kgs packaging Fiber drum outside and plastic bag inside 1-25kgs packaging ;
aluminium bag outside and double plastic bag inside;
Delivery Detail:
Within 3 days when get the payment. 
Shipping:
We have Professional shipping agent, based on customers ' demand for transport
By express :FEDEX,DHL,EMS ,UPS,TNT ect.
By SEA and By AIR.

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FAQ

Q1. What's the MOQ?
A: Usually 1 kg. It is based on the different product. Some are 1g and some are 1 ton. Please be free to consult our salesman.

Q2. What's the shipping time?
A: If in stock, we will ship it out immediately. By FeDex will be 3~5 days to you.

Q3. If I need less than the MOQ, is it possible?
A: Yes. Please be free to consult our salesman.

Q4. Can you supply the free sample?
A: Usually it is possible. It based on the different product. Please be free to consult our salesman.

Q5. How to store the product?
A: Store in cool and dry place. It must be in well closed containers.The shelf life will be 2 years.

Q6: What's your main payment method?
A: T/T, Western Union, Money Gram, Paypal.

Q7: Do you have COA, MSDS, CO, Health certificate, form 9 or other certificate?
A: Yes, we have. pls be free to contact us to get updated one.